Evaluation of antibiotic resistance

The resistance to antibiotics represents today one of the most serious threats to global health. 
To understand the mechanisms of resistance set up by bacteria in order to forestall them, SMALTIS offers you its Know-how.

Our Methods: 

      In vitro measurement of antibiotic resistance:

To measure in vitro how sensitive your strains are to antibiotics by defining the Minimal Inhibitory Concentrations (MIC), the Minimal Bactericidal Concentrations (MBC), carrying out antibiogrammes and E-tests or by defining the FIC-Index (Fractional Inhibitory Concentration) further to recommendations from the CLSI (Clinical & Laboratory Standards Institute) and the CA-SFM/EUCAST (Comité de l’Antibiogramme de la Société Française de Microbiologie/European Committee on Antimicrobial Susceptibility Testing).

      
In vitro measurement of antibiotic efficiency:
 
To measure in vitro the efficiency of your anti-infectious molecules by carrying out a bactericidal curve further to recommendations from the CLSI (Clinical & Laboratory Standards Institute) and the CA-SFM/EUCAST (Comité de l’Antibiogramme de la Société Française de Microbiologie/European Committee on Antimicrobial Susceptibility Testing).
 
      Evaluation of the capacities of your strains to develop resistances:

To assess the bacteria’s capacity to develop resistance to your anti-infectious molecules by selecting resistant spontaneous mutants, by assessing their frequency of appearance, by characterizing the resistant mechanisms involved, by identifying mutations and by reconstructing the regulation pathways leading to the increase in resistance.

The assessment of resistance to antibiotics may be performed on your strains. We may also use our own collections of characterized clinical samples. Indeed, SMALTIS has access to a Bioressources containing more than 40 000 Bacterial strains from all around the world.

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Our References: 

Juarez et al, 2018
Juarez et al, 2017

Richardot et al, 2016
Guenard et al, 2014
Buick et al, 2012
Muller et al, 2011
Vettoretti et al, 2009
                                                                                                                                                                                    
Our services:

Identification of Microorganism
Phenotyping
Genotyping
Measurement of virulence factors