Global microbiota

SMALTIS' expertise makes it possible to explore the human microbiota (intestines, ENT, lungs, urinary tract, vagina, skin, stomach...) and to support programs related to it.

Thus, SMALTIS supports the development and the control of candidates targeting or derived from the microbiota, such as:  Live Biotherapeutic Products, Probiotics, Drugs.

Specific expertise: post-metagenomic studies to understand and describe mechanisms of action, and study efficacy of products:
 
›        DESCRIBE microbiota by metagenomic and metatranscriptomic analysis
›        EXPLAIN interactions between bacteria and candidates
›        UNDERSTAND impact of a stimulus or candidate on strains of interest
›        IDENTIFY specific properties or biomarkers
›        CHARACTERIZE & CONTROL stability of strains

Tools:

›        Next Generation Sequencing
›        Metagenomics, Metatranscriptomics
›        Identification & Quantification
›        Culture & Viability
›        Characterization of properties
          → Morphology, physiology, biochemistry, adhesion, resistance, virulence
›        Genotyping

Models:

›        Cultures & co-cultures of bacteria of interest
         → Available bacterial collections
         → Construction of custom-made strains

›        Cellular infections
         → Intestinal, pulmonary and macrophage cells

›        Ex vivo biological samples
         → Biopsies, skin explants...